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PE-22-28 (10mg)

PE-22-28 (10mg)

Original price was: $110.00.Current price is: $59.00.

PE-22-28 is a spadin-derived 7-amino-acid peptide fragment supplied as a lyophilized research compound, studied in controlled research environments for TREK-1 channel inhibition and BDNF-pathway modulation in research models. For research use only.

SKU: RRL.PE228.10 Categories: ,

Description

PE-22-28 is a synthetic 7-amino-acid peptide fragment derived from spadin, a naturally occurring peptide that inhibits TREK-1 potassium channels in research-model brain tissue. Supplied as a lyophilized research-grade compound for use in controlled research environments, PE-22-28 is investigated for its capacity to indirectly amplify BDNF signaling via TREK-1 modulation.

About PE-22-28 (10mg)

PE-22-28 represents a newer class of BDNF-modulating research peptides. Its mechanism — TREK-1 channel inhibition — is distinct from classical neurotrophic compounds and has drawn research interest for its rapid onset in research models.

What It's Being Studied To Do

  • Rapidly increase BDNF expression in research-model brain tissue
  • Enhance neuroplasticity and synaptic-strength markers
  • Influence mood-regulation pathways in depressive-like research models
  • Improve stress resilience markers and adaptability in research models
  • Probe TREK-1-mediated neurotrophic signaling
  • Examine neuronal changes under chronic stress in research models

Why It Matters in Research

Low BDNF expression is associated with diminished cognitive flexibility and stress-handling capacity in research models. PE-22-28 research explores how rapidly amplifying neurotrophic signaling alters research-model outcomes, complementing traditional research compounds in this space.

Common Research Pairings

  • Semax — BDNF + cognitive pathway research
  • Selank — stress-balance research
  • Dihexa / Cerebrolysin — synaptogenesis research
  • NAD+ — cellular energy substrate

Quick Facts

  • Class: Spadin-derived peptide fragment
  • Structure: 7 amino acids
  • Mechanism: TREK-1 potassium-channel inhibition
  • Dosage form: Lyophilized powder, 10 mg per sealed research vial
  • Status: Research use only
For Research Use Only. Not for human or veterinary use. Not a drug, dietary supplement, or food product. Not approved by the FDA.

Additional information

Weight 0.0625 lbs

Storage Instructions

All products from Rhema Research Labs are manufactured using a lyophilization (freeze-drying) process. This method is designed to maintain product integrity and allows vials to remain stable during shipping for approximately 3–4 months.

Once a vial is reconstituted with bacteriostatic water, it should be stored in the refrigerator to help maintain stability. Under these conditions, reconstituted material is generally considered stable for up to 30 days.

Lyophilization is a dehydration technique in which compounds are frozen and then exposed to low pressure. This causes the water in the vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure. This powder can be kept at room temperature until reconstitution.

Upon receipt, products should be stored away from heat and light. For short-term use, refrigeration at approximately 4°C (39°F) is suitable. For long-term storage (several months to years), vials may be placed in a freezer at approximately -80°C (-112°F). Freezing is the preferred method for preserving product stability over extended periods.

⚠️ Important Notice:
These products are intended for research use only. Not for human consumption.

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Frequently Asked Questions

Essential information about our research-grade peptides and quality standards.

Peptides are short chains of amino acids linked by peptide bonds, typically consisting of 2-50 amino acids. They serve as the building blocks of proteins and play crucial roles in biological processes.

Research peptides are synthesized versions of naturally occurring peptides, manufactured to precise specifications for use in scientific studies.

Key characteristics: High purity (≥99%), lyophilized form for stability, accompanied by Certificates of Analysis (COA), and manufactured under strict quality control protocols.

Peptide purity refers to the percentage of the target peptide present in a sample, measured via High-Performance Liquid Chromatography (HPLC).

Our Standard: All our research peptides maintain ≥99% purity, verified by third-party laboratory testing and documented in our Certificates of Analysis.

Higher purity is critical for research because impurities can interfere with experimental results and compromise the reproducibility of studies.

All products are supplied in lyophilized powder form within sterile, sealed vials. This format provides:

  • Maximum stability: Extended shelf life compared to liquid solutions
  • Precise measurement: Researchers can work with desired quantities
  • Contamination protection: Sealed vials prevent environmental exposure
  • Shipping durability: Powder form is more stable during transit

Lyophilized peptides:

  • Store at -4°F for long-term storage (up to 24 months)
  • Store at 36-46°F (refrigerated) for short-term storage (up to 3 months)
  • Keep away from light, moisture, and repeated temperature fluctuations

We supply research-grade peptides to:

  • Academic and university research laboratories
  • Pharmaceutical and biotechnology companies
  • Independent research institutions
  • Licensed professionals conducting legitimate scientific research

We maintain rigorous quality control through a multi-step verification process:

  • HPLC Analysis: Every batch tested to verify ≥99% purity
  • Mass Spectrometry: Molecular weight confirmation for peptide identity
  • Third-Party Testing: Independent laboratory verification
  • Sterility Protocols: Aseptic handling and packaging procedures
  • Batch Documentation: Complete traceability from synthesis to delivery

"Research Use Only" (RUO) is a classification indicating that a product is intended exclusively for laboratory research and experimental investigation.

All orders are shipped with research-grade handling protocols:

  • Packaging: Insulated containers with cold packs when required
  • Carriers: USPS Priority Mail
  • Processing: Orders placed before 12 PM EST ship same business day
  • Tracking: Full tracking information provided via email

We stand behind every product:

  • Quality guarantee: Full replacement or refund if products don't meet stated specifications
  • Shipping issues: Free replacement for damaged or lost shipments
  • Unopened returns: Accepted within 30 days for store credit
Rhema Research Labs
Research Peptides

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RESEARCH USE ONLY: All peptides sold on this site are intended for laboratory research purposes only. Products are not for human consumption or medical use.

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